As we age, our skin tells a story, fine lines deepen, elasticity fades, and that youthful glow begins to dim. But what if science could help rewrite that story? In the ever-evolving world of skincare, two breakthrough ingredients are turning back time in the most luxurious way: stem cells and gold. Once reserved for the elite, these powerhouse actives are now at the forefront of advanced anti-aging treatments, offering real, visible results for mature skin. If you’re looking to revive firmness, boost radiance, and restore vitality, it’s time to understand why stem cells and gold are the future of timeless beauty.

Skin Aging

Skin aging is a complex process which involves all the layers of the epidermis and dermis. Internal and external factors influence this process.

The most important external factor in skin aging is UV radiation, which causes photoaging of the skin. The free radicals that are formed as a result of the UV radiation cause the degradation of unsaturated lipids of the intercellular cement, gaps in the lipid barrier of the skin and, as a result, increased TEWL, and changes in the structure of fibrillar proteins–collagen and elastin.

The internal factors that cause changes in the skin structure are, primarily, physiological disorders in the rate of epidermis exfoliation, inhibition of tissue regeneration, and inhibition of tissue growth and differentiation processes. The reduction of the regenerative potential of the skin is the result of, among other factors, lower activity of the stem cells.

Your skin changes as you get older, and this happens for a few main reasons happening inside your body.

1. The skin doesn’t shed old cells like it used to.
2. The skin doesn’t heal or grow new cells as well.
3. The stem cells (which help make new skin) get lazy or stop working.

Stem cells are like the starter cells that help your skin repair itself. When they stop working well, your skin doesn’t fix itself like it used to.

The Cellular Mechanisms Behind Skin Aging

There are two major biological mechanisms that limit how often human skin cells can divide and regenerate:

1. Replicative Aging and Telomere Shortening

Each time a cell divides, the protective caps on the ends of chromosomes ( called telomeres ) become shorter. Telomeres are essential for DNA stability, and when they get too short, the cell can no longer divide. This is especially true for fibroblasts, the cells that maintain skin structure and elasticity. This process, known as replicative aging, leads to fewer active fibroblasts and contributes to visible signs of skin aging.

2. Premature Aging from Oxidative Stress

Cells can also age early due to oxidative stress — a condition where harmful molecules called reactive oxygen species (ROS) damage the DNA.

Telomeres are particularly sensitive to this kind of stress because they contain a lot of guanine, a DNA base that’s easily oxidized. When telomeres are damaged by ROS, DNA replication is disrupted, telomeres shorten more quickly, and cells stop dividing earlier than they should.

How Oxidative Stress Accelerates Skin Aging

Long-term exposure to internal stressors, including oxidative damage, can lead to telomeric DNA damage, especially at the 3’ ends of telomeres. This not only interrupts DNA replication but also causes accelerated telomere shortening. As a result, the affected skin cells lose their ability to renew, regenerate, and maintain skin health.

One effective way to protect your skin from the damaging effects of reactive oxygen species (ROS) is by applying broad-spectrum sunscreen. Sunscreen helps block harmful UV rays, which are a major external source of oxidative stress and DNA damage. As we discussed in our: The Complete Guide to Selecting the Right Sunscreen for Your Skin Type – د. حلو consistent use of sun protection can significantly reduce the rate of skin aging and help preserve the skin’s regenerative ability.

Stem Cells in Skincare

Stem cells are long-living, self-renewing cells that can differentiate into specialized cell types, including epidermal keratinocytes and dermal fibroblasts, making them essential for tissue regeneration and skin repair.

Stem cells are found in plant and animal organisms. They differ from other cells due to their unusual properties, proliferation ability (continuous multiplication), and differentiation into specialized cells (depending on the organ in which they are present), and they are also responsible for the growth and repair of damaged tissues.

The extracts derived from plant stem cells are the source of many active substances that are safe for the human body, because they do not produce the response of the immune system. Their acquisition is environmentally friendly and possible even in the case of hard to reach or endangered plants, without causing interference and disturbance in their natural habitat.

 

The plant stem cells are responsible for many positive cosmetic effects, such as:

• extending the life of fibroblasts and stimulating their activity
• increasing the flexibility of the epidermis
• regulating cell division
• rebuilding damaged epidermis
• activating DNA repair of the cells, protecting them from oxidative stress
• protecting against UV radiation

Gold in Skincare

In recent years, gold has found its way into the cosmetic industry, particularly in anti-aging products. Gold nanoparticles are incorporated into various skincare formulations, including creams, serums, and facial masks, with claims of enhancing skin radiance and reducing signs of aging. These products often market themselves as luxurious treatments aimed at rejuvenating the skin. But how does gold work for aged skin?

Gold has anti-inflammatory properties and has been used in medicine for this reason. It can help reduce inflammation in irritated skin, particularly in mature skin. Additionally, gold may combat oxidative stress caused by reactive oxygen species (ROS) by neutralizing them, which could protect collagen and elastin from degradation.

Moreover, gold acts as a delivery agent, aiding other ingredients in penetrating deeper into the skin for more effective results.

Taking this into consideration, Dr. Hilo developed a premium skincare formula that combines luxurious plant stem cells and 24K gold using advanced biotechnological processes, expertly crafted to nourish and rejuvenate your skin.

Gold (24k) Serum with Stem-Cells for wrinkles

24k Gold Serum from Dr.Hilo gives the face a unique brightness with its pure gold flakes. It is effective for Anti-Aging as it contains high concentrations of Hyaluronic Acid and Stem Cells extracted by biotechnology, which helps to fill fine lines of the skin. It also maintains high moisturizing and nourishing of the skin which results in healthy and youthful appearance. Gold Serum (24K) for wrinkles – د. حلو

 

References:

1. Miastkowska, Małgorzata, and Elżbieta Sikora. “Anti-Aging Properties of Plant Stem Cell Extracts.” Cosmetics, vol. 5, no. 4, 22 Sept. 2018, p. 55, www.mdpi.com/2079-9284/5/4/55/htm, https://doi.org/10.3390/cosmetics5040055.
2. Dahl, Mark V. “Stem Cells and the Skin.” Journal of Cosmetic Dermatology, vol. 11, no. 4, 23 Nov. 2012, pp. 297–306, https://doi.org/10.1111/jocd.12008.
3. Bogg, Anna. “Skin Complications of Gold Treatment.” Acta Rheumatologica Scandinavica, vol. 4, no. 1-4, 1 Dec. 1958, pp. 86–97, https://doi.org/10.3109/rhe1.1958.4.issue-1-4.11. Accessed 4 May 2025.